2023-05-25 ワシントン大学セントルイス校
◆超音波の刺激により、マウスの体温が約3℃下がり、代謝も脂質のみに切り替わり、心拍数も約47%低下しました。この研究は、非侵襲的な冬眠状態の誘発が可能であり、将来的に医療や宇宙飛行などへの応用が期待されています。
<関連情報>
- https://source.wustl.edu/2023/05/induction-of-a-torpor-like-state-with-ultrasound/
- https://www.nature.com/articles/s42255-023-00804-z
超音波を用いたげっ歯類の冬眠状態の低体温・低代謝状態の誘導について Induction of a torpor-like hypothermic and hypometabolic state in rodents by ultrasound
Yaoheng Yang,Jinyun Yuan,Rachael L. Field,Dezhuang Ye,Zhongtao Hu,Kevin Xu,Lu Xu,Yan Gong,Yimei Yue,Alexxai V. Kravitz,Michael R. Bruchas,Jianmin Cui,Jonathan R. Brestoff & Hong Chen
Nature Metabolism Published:25 May 2023
DOI:https://doi.org/10.1038/s42255-023-00804-z
Abstract
Torpor is an energy-conserving state in which animals dramatically decrease their metabolic rate and body temperature to survive harsh environmental conditions. Here, we report the noninvasive, precise and safe induction of a torpor-like hypothermic and hypometabolic state in rodents by remote transcranial ultrasound stimulation at the hypothalamus preoptic area (POA). We achieve a long-lasting (>24 h) torpor-like state in mice via closed-loop feedback control of ultrasound stimulation with automated detection of body temperature. Ultrasound-induced hypothermia and hypometabolism (UIH) is triggered by activation of POA neurons, involves the dorsomedial hypothalamus as a downstream brain region and subsequent inhibition of thermogenic brown adipose tissue. Single-nucleus RNA-sequencing of POA neurons reveals TRPM2 as an ultrasound-sensitive ion channel, the knockdown of which suppresses UIH. We also demonstrate that UIH is feasible in a non-torpid animal, the rat. Our findings establish UIH as a promising technology for the noninvasive and safe induction of a torpor-like state.
