2023-08-09 カリフォルニア大学サンディエゴ校(UCSD)
◆この治療法は、ミクログリアという脳内の免疫細胞に影響を与え、アルツハイマー病の進行を軽減する効果があるとされています。
<関連情報>
- https://today.ucsd.edu/story/stem-cell-therapy-rescues-symptoms-of-alzheimers-disease
- https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00967-1
野生型造血幹細胞および前駆細胞の移植によるアルツハイマー病モデルマウスの表現型の救済 Rescue of Alzheimer’s disease phenotype in a mouse model by transplantation of wild-type hematopoietic stem and progenitor cells
Priyanka Mishra,Alexander Silva,Jay Sharma,Jacqueline Nguyen,Donald P. Pizzo,Denise Hinz,Debashis Sahoo,Stephanie Cherqui
Cell Reports Published:August 08, 2023
DOI:https://doi.org/10.1016/j.celrep.2023.112956
Highlights
•WT HSPC transplantation rescues memory and neurocognitive decline
•WT HSPC transplantation reduces Aβ plaque density and partially preserves blood-brain integrity
•WT HSPC transplantation may prevent microgliosis and neuroinflammation
Summary
Alzheimer’s disease (AD) is the most prevalent cause of dementia; microglia have been implicated in AD pathogenesis, but their role is still matter of debate. Our study showed that single systemic wild-type (WT) hematopoietic stem and progenitor cell (HSPC) transplantation rescued the AD phenotype in 5xFAD mice and that transplantation may prevent microglia activation. Indeed, complete prevention of memory loss and neurocognitive impairment and decrease of β-amyloid plaques in the hippocampus and cortex were observed in the WT HSPC-transplanted 5xFAD mice compared with untreated 5xFAD mice and with mice transplanted with 5xFAD HSPCs. Neuroinflammation was also significantly reduced. Transcriptomic analysis revealed a significant decrease in gene expression related to “disease-associated microglia” in the cortex and “neurodegeneration-associated endothelial cells” in the hippocampus of the WT HSPC-transplanted 5xFAD mice compared with diseased controls. This work shows that HSPC transplant has the potential to prevent AD-associated complications and represents a promising therapeutic avenue for this disease.
