2023-11-15 レンセラー工科大学 (RPI)
◆研究者は、バイオプリント技術を適用した細胞レベルでの3Dプリントを使用し、毛包を構造する皮膚細胞と毛細胞を混ぜた「バイオインク」を極めて細い針を用いて層状に積層しました。現在はこれらの組織の寿命が2〜3週間であり、毛軸が発達するには不十分ですが、今後の研究ではこの期間を延長し、薬物テストや皮膚移植に活用する方針です。
<関連情報>
- https://news.rpi.edu/content/2023/11/15/scientists-3d-print-hair-follicles-lab-grown-skin
- https://www.science.org/doi/10.1126/sciadv.adg0297
ヒト皮膚の3Dバイオプリントモデルに毛包を組み込む Incorporation of hair follicles in 3D bioprinted models of human skin
Carolina Motter Catarino,Desiree Cigaran Schuck,Lexi Dechiario,and Pankaj Karande
Science Advances Published:13 Oct 2023
DOI:https://doi.org/10.1126/sciadv.adg0297
Abstract
Current approaches fail to adequately introduce complex adnexal structures such as hair follicles within tissue engineered models of skin. Here, we report on the use of 3D bioprinting to incorporate these structures in engineered skin tissues. Spheroids, induced by printing dermal papilla cells (DPCs) and human umbilical vein cells (HUVECs), were precisely printed within a pregelled dermal layer containing fibroblasts. The resulting tissue developed hair follicle–like structures upon maturation, supported by migration of keratinocytes and melanocytes, and their morphology and composition grossly mimicked that of the native skin tissue. Reconstructed skin models with increased complexity that better mimic native adnexal structures can have a substantial impact on regenerative medicine as grafts and efficacy models to test the safety of chemical compounds.
