科学者ら、捕食性細菌が獲物を認識する仕組みの謎を解明(Scientists solve mystery of how predatory bacteria recognizes prey)

ad

2024-01-04 バーミンガム大学

◆バーミンガム大学とノッティンガム大学の研究者は、自然の抗菌捕食性細菌であるBdellovibrio bacterivorousが、獲物を捕えるために表面に繊維状のタンパク質を生成する仕組みを発見しました。この発見により、これらの捕食者を利用して、医療、食品の劣化、環境に問題を引き起こす有害な細菌を標的にして殺す手段が可能になるかもしれません。

<関連情報>

Bdellovibrio bacteriovorusがキメラ繊維タンパク質を用いて様々な宿主細菌を認識し侵入することを発見 Bdellovibrio bacteriovorus uses chimeric fibre proteins to recognize and invade a broad range of bacterial hosts

Simon G. Caulton,Carey Lambert,Jess Tyson,Paul Radford,Asmaa Al-Bayati,Samuel Greenwood,Emma J. Banks,Callum Clark,Rob Till,Elisabete Pires,R. Elizabeth Sockett & Andrew L. Lovering
Nature Microbiology  Published:04 January 2024
DOI:https://doi.org/10.1038/s41564-023-01552-2

科学者ら、捕食性細菌が獲物を認識する仕組みの謎を解明(Scientists solve mystery of how predatory bacteria recognizes prey)

Abstract

Predatory bacteria, like the model endoperiplasmic bacterium Bdellovibrio bacteriovorus, show several adaptations relevant to their requirements for locating, entering and killing other bacteria. The mechanisms underlying prey recognition and handling remain obscure. Here we use complementary genetic, microscopic and structural methods to address this deficit. During invasion, the B. bacteriovorus protein CpoB concentrates into a vesicular compartment that is deposited into the prey periplasm. Proteomic and structural analyses of vesicle contents reveal several fibre-like proteins, which we name the mosaic adhesive trimer (MAT) superfamily, and show localization on the predator surface before prey encounter. These dynamic proteins indicate a variety of binding capabilities, and we confirm that one MAT member shows specificity for surface glycans from a particular prey. Our study shows that the B. bacteriovorus MAT protein repertoire enables a broad means for the recognition and handling of diverse prey epitopes encountered during bacterial predation and invasion.

生物化学工学
ad
ad
Follow
ad
タイトルとURLをコピーしました