強力な抗生物質に耐性を持つ新型の高感染性大腸菌が発見される(New and highly infectious E. coli strain resistant to powerful antibiotics)

2024-01-31 バーミンガム大学

<関連情報>

• https://www.birmingham.ac.uk/news/2024/new-and-highly-infectious-e.-coli-strain-resistant-to-powerful-antibiotics
• https://www.nature.com/articles/s41467-023-43854-3

高病原性カルバペネム耐性大腸菌ST410クローンの世界的出現 Global emergence of a hypervirulent carbapenem-resistant Escherichia coli ST410 clone

Xiaoliang Ba,Yingyi Guo,Robert A. Moran,Emma L. Doughty,Baomo Liu,Likang Yao,Jiahui Li,Nanhao He,Siquan Shen,Yang Li,Willem van Schaik,Alan McNally,Mark A. Holmes & Chao Zhuo
Nature Communications  Published:12 January 2024
DOI:https://doi.org/10.1038/s41467-023-43854-3

Abstract

Carbapenem-resistant Escherichia coli (CREC) ST410 has recently emerged as a major global health problem. Here, we report a shift in CREC prevalence in Chinese hospitals between 2017 and 2021 with ST410 becoming the most commonly isolated sequence type. Genomic analysis identifies a hypervirulent CREC ST410 clone, B5/H24RxC, which caused two separate outbreaks in a children’s hospital. It may have emerged from the previously characterised B4/H24RxC in 2006 and has been isolated in ten other countries from 2015 to 2021. Compared with B4/H24RxC, B5/H24RxC lacks the bla_OXA-181-bearing X3 plasmid, but carries a F-type plasmid containing bla_NDM-5. Most of B5/H24RxC also carry a high pathogenicity island and a novel O-antigen gene cluster. We find that B5/H24RxC grew faster in vitro and is more virulent in vivo. The identification of this newly emerged but already globally disseminated hypervirulent CREC clone, highlights the ongoing evolution of ST410 towards increased resistance and virulence.