2024-03-07 カリフォルニア大学リバーサイド校(UCR)
<関連情報>
- https://news.ucr.edu/articles/2024/03/07/doctors-can-now-watch-spinal-cord-activity-during-surgery
- https://www.cell.com/neuron/fulltext/S0896-6273(24)00122-3
ヒト脊髄の機能的超音波イメージング Functional ultrasound imaging of the human spinal cord
K.A. Agyeman,D.J. Lee,J. Russin,…,V.R. Edgerton,C. Liu,V.N. Christopoulos
Neuron Published:March 07, 2024
DOI:https://doi.org/10.1016/j.neuron.2024.02.012
Highlights
•Functional ultrasound imaging detects stimulation-induced responses in the spinal cord
•fUSI decodes the effectiveness of an electrical stimulation in a single trial
•A crucial step to study spinal cord function and effects of clinical neuromodulation
Summary
Utilizing the first in-human functional ultrasound imaging (fUSI) of the spinal cord, we demonstrate the integration of spinal functional responses to electrical stimulation. We record and characterize the hemodynamic responses of the spinal cord to a neuromodulatory intervention commonly used for treating pain and increasingly used for the restoration of sensorimotor and autonomic function. We found that the hemodynamic response to stimulation reflects a spatiotemporal modulation of the spinal cord circuitry not previously recognized. Our analytical capability offers a mechanism to assess blood flow changes with a new level of spatial and temporal precision in vivo and demonstrates that fUSI can decode the functional state of spinal networks in a single trial, which is of fundamental importance for developing real-time closed-loop neuromodulation systems. This work is a critical step toward developing a vital technique to study spinal cord function and effects of clinical neuromodulation.
