研究者がコロナウイルスワクチンを開発(Georgia Tech Researchers Develop More Broadly Protective Coronavirus Vaccine)

ad

2024-04-01 ジョージア工科大学

ジョージア工科大学とウィスコンシン大学マディソン校の研究者は、SARS-CoV-2変異株だけでなく、他にコウモリのSarbecovirusesにも広範な保護を提供する新しい3価ワクチンを開発しました。このワクチンは、肺にウイルスの痕跡がない完全な保護を示し、コロナウイルスの普遍的ワクチンへの重要な一歩となります。

<関連情報>

スパイク・タンパク質・ナノ粒子のカクテルワクチンによる1回の免疫でクレード1サルベコウイルスに対する幅広い防御が得られる Broad protection against clade 1 sarbecoviruses after a single immunization with cocktail spike-protein-nanoparticle vaccine

Peter J. Halfmann,Kathryn Loeffler,Augustine Duffy,Makoto Kuroda,Jie E. Yang,Elizabeth R. Wright,Yoshihiro Kawaoka & Ravi S. Kane
Nature Communications  Published:12 February 2024
DOI:https://doi.org/10.1038/s41467-024-45495-6

研究者がコロナウイルスワクチンを開発(Georgia Tech Researchers Develop More Broadly Protective Coronavirus Vaccine)

Abstract

The 2002 SARS outbreak, the 2019 emergence of COVID-19, and the continuing evolution of immune-evading SARS-CoV-2 variants together highlight the need for a broadly protective vaccine against ACE2-utilizing sarbecoviruses. While updated variant-matched formulations are a step in the right direction, protection needs to extend beyond SARS-CoV-2 and its variants to include SARS-like viruses. Here, we introduce bivalent and trivalent vaccine formulations using our spike protein nanoparticle platform that completely protect female hamsters against BA.5 and XBB.1 challenges with no detectable virus in the lungs. The trivalent cocktails elicit highly neutralizing responses against all tested Omicron variants and the bat sarbecoviruses SHC014 and WIV1. Finally, our 614D/SHC014/XBB trivalent spike formulation completely protects human ACE2-transgenic female hamsters against challenges with WIV1 and SHC014 with no detectable virus in the lungs. Collectively, these results illustrate that our trivalent protein-nanoparticle cocktail can provide broad protection against SARS-CoV-2-like and SARS-CoV-1-like sarbecoviruses.

有機化学・薬学
ad
ad
Follow
ad
タイトルとURLをコピーしました