ストレスが認知予備力を奪う(How stress knocks out your cognitive reserve)

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2024-04-06 カロリンスカ研究所(KI)

カロリンスカ研究所の新研究によると、記憶クリニックの患者において精神的に刺激的な活動や人生経験が認知機能を向上させる一方、ストレスはこの関係を損なうことが判明しました。認知予備力は教育や複雑な仕事、身体活動、健康な社会的交流によって構築されるが、高ストレスはこれらを妨げ、認知症リスクを増加させます。研究では、認知予備力が認知機能を改善するが、生理的ストレスがその効果を弱めることが示されました。ストレス管理の戦略がアルツハイマー予防に役立つ可能性があります。

<関連情報>

認知予備能、コルチゾール、アルツハイマー病バイオマーカー: メモリークリニック研究 Cognitive reserve, cortisol, and Alzheimer’s disease biomarkers: A memory clinic study

Manasa Shanta Yerramalla, Alexander Darin-Mattsson, Chinedu T Udeh-Momoh, Jasper Holleman, Ingemar Kåreholt, Malin Aspö, Göran Hagman, Miia Kivipelto, Alina Solomon, Anna Marseglia, Shireen Sindi
Alzheimer’s & Dementia  Published: 04 June 2024
DOI:https://doi.org/10.1002/alz.13866

ストレスが認知予備力を奪う(How stress knocks out your cognitive reserve)

Abstract

INTRODUCTION
Cognitive reserve might mitigate the risk of Alzheimer’s dementia among memory clinic patients. No study has examined the potential modifying role of stress on this relation.

METHODS
We examined cross-sectional associations of the cognitive reserve index (CRI; education, occupational complexity, physical and leisure activities, and social health) with cognitive performance and AD-related biomarkers among 113 memory clinic patients. The longitudinal association between CRI and cognition over a 3-year follow-up was assessed. We examined whether associations were influenced by perceived stress and five measures of diurnal salivary cortisol.

RESULTS
Higher CRI scores were associated with better cognition. Adjusting for cortisol measures reduced the beneficial association of CRI on cognition. A higher CRI score was associated with better working memory in individuals with higher (favorable) cortisol AM/PM ratio, but not among individuals with low cortisol AM/PM ratio. No association was found between CRI and AD-related biomarkers.

DISCUSSION
Physiological stress reduces the neurocognitive benefits of cognitive reserve among memory clinic patients.

Highlights

  • Physiological stress may reduce the neurocognitive benefits accrued from cognitively stimulating and enriching life experiences (cognitive reserve [CR]) in memory clinic patients.
  • Cortisol awakening response modified the relation between CR and P-tau181, a marker of Alzheimer’s disease (AD).
  • Effective stress management techniques for AD and related dementia prevention are warranted.
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