2024-09-19 シンガポール国立大学(NUS)
<関連情報>
- https://news.nus.edu.sg/novel-approach-to-rejuvenate-aged-egg-cells/
- https://www.nature.com/articles/s43587-024-00697-x
若い卵胞微小環境への曝露による老化卵子の若返り Rejuvenation of aged oocyte through exposure to young follicular microenvironment
HaiYang Wang,Zhongwei Huang,Xingyu Shen,Yaelim Lee,XinJie Song,Chang Shu,Lik Hang Wu,Leroy Sivappiragasam Pakkiri,Poh Leong Lim,Xi Zhang,Chester Lee Drum,Jin Zhu & Rong Li
Nature Aging Published:09 September 2024
DOI:https://doi.org/10.1038/s43587-024-00697-x
Abstract
Reproductive aging is a major cause of fertility decline, attributed to decreased oocyte quantity and developmental potential. A possible cause is aging of the surrounding follicular somatic cells that support oocyte growth and development by providing nutrients and regulatory factors. Here, by creating chimeric follicles, whereby an oocyte from one follicle was transplanted into and cultured within another follicle whose native oocyte was removed, we show that young oocytes cultured in aged follicles exhibited impeded meiotic maturation and developmental potential, whereas aged oocytes cultured within young follicles were significantly improved in rates of maturation, blastocyst formation and live birth after in vitro fertilization and embryo implantation. This rejuvenation of aged oocytes was associated with enhanced interaction with somatic cells, transcriptomic and metabolomic remodeling, improved mitochondrial function and higher fidelity of meiotic chromosome segregation. These findings provide the basis for a future follicular somatic cell-based therapy to treat female infertility.
