最古の現生人類のゲノムが解読される(Oldest modern human genomes sequenced)

ad

2024-12-12 マックス・プランク研究所

最古の現生人類のゲノムが解読される(Oldest modern human genomes sequenced)

Illustration of Zlatý kůň, who belonged to the same population as the Ranis individuals and was closely related to two of them.
© Tom Björklund for Max Planck Institute for Evolutionary Anthropology

マックス・プランク進化人類学研究所の研究者らは、約4万2,000年から4万9,000年前に生きた7人の初期現生人類のゲノムを解読しました。これらの個体は、アフリカを約5万年前に離れた集団から早期に分岐した小規模で密接に関連したグループに属していました。彼らのゲノムには、非アフリカ系現生人類に共通するネアンデルタール人との混血の痕跡が含まれており、この混血イベントは約5万年前に起こったと推定されています。しかし、これらの初期現生人類の遺伝的系統は現代人には受け継がれておらず、絶滅したことが示唆されています。

<関連情報>

最古の現生人類のゲノムからネアンデルタール人との混血時期が特定される Earliest modern human genomes constrain timing of Neanderthal admixture

Arev P. Sümer,Hélène Rougier,Vanessa Villalba-Mouco,Yilei Huang,Leonardo N. M. Iasi,Elena Essel,Alba Bossoms Mesa,Anja Furtwaengler,Stéphane Peyrégne,Cesare de Filippo,Adam B. Rohrlach,Federica Pierini,Fabrizio Mafessoni,Helen Fewlass,Elena I. Zavala,Dorothea Mylopotamitaki,Raffaela A. Bianco,Anna Schmidt,Julia Zorn,Birgit Nickel,Anna Patova,Cosimo Posth,Geoff M. Smith,Karen Ruebens,… Johannes Krause
Nature  Published:12 December 2024
DOI:https://doi.org/10.1038/s41586-024-08420-x

We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript will undergo further editing. Please note there may be errors present which affect the content, and all legal disclaimers apply.

Abstract

Modern humans arrived in Europe more than 45,000 years ago, overlapping at least 5,000 years with Neanderthals1–4. Limited genomic data from these early modern humans have shown that at least two genetically distinct groups inhabited Europe, represented by Zlatý kůň, Czechia3 and Bacho Kiro, Bulgaria2. Here we deepen our understanding of early modern humans by analyzing one high-coverage genome and five low-coverage genomes from ~45,000 year-old remains from Ilsenhöhle in Ranis, Germany4, and a further high-coverage genome from Zlatý kůň. We show that distant familial relationships link the Ranis and Zlatý kůň individuals and that they were part of the same small, isolated population that represents the deepest known split from the Out-of-Africa lineage. Ranis genomes harbor Neanderthal segments that originate from a single admixture event shared with all non-Africans that we date to ~45,000-49,000 years ago. This implies that ancestors of all non-Africans sequenced to-date resided in a common population at this time, and further suggests that modern human remains older than 50,000 years from outside Africa represent different non-African populations.

細胞遺伝子工学
ad
ad
Follow
ad
タイトルとURLをコピーしました