2025-03-01 中国科学院(CAS)
Neural cell competition in development, homeostasis and disease. (Image by GAO Lisen)
<関連情報>
- https://english.cas.cn/newsroom/research_news/life/202503/t20250304_903023.shtml
- https://academic.oup.com/nsr/advance-article/doi/10.1093/nsr/nwaf057/8026888?login=false
ゆりかごから墓場まで脳を彫刻する神経細胞の競争 Neural Cell Competition Sculpting Brain from Cradle to Grave
Yu Zheng Li, Lisen Gao, Xue-Lian Sun, Lihui Duan, Man Jiang, Qing-Feng Wu
National Science Review Published:20 February 2025
DOI:https://doi.org/10.1093/nsr/nwaf057
Abstract
Darwinian selection, operating within the cellular ecosystem of multicellular organisms, drives a pervasive surveillance mechanism of cell-cell competition that shapes tissue architecture and function. While cell competition eliminates suboptimal cells to ensure tissue integrity across various tissues, neuronal competition specifically sculpts neural networks to establish precise circuits for sensory, motor, and cognitive functions. However, our understanding of cell competition across diverse neural cell types in both developmental and pathological contexts remains limited. Here, we review recent advances on the phenomenon, mechanisms, and potential functions of neural cell competition, ranging from neural progenitors, neurons, astrocytes, oligodendrocytes, to microglia. Physiological neural cell competition governs cellular survival, proliferation, arborization, organization, function, and territorial colonization, whereas dysregulated neural cell competition may cause neurodevelopmental disorders, accelerate aging, exacerbate neurodegenerative diseases, and drive brain tumor progression. Future work leveraging cell competition mechanisms may help to improve cognition and curb diseases.
