2025-04-02 ノースウェスタン大学
<関連情報>
- https://news.northwestern.edu/stories/2025/03/worlds-smallest-pacemaker-is-activated-by-light/
- https://www.nature.com/articles/s41586-025-08726-4
- https://www.nature.com/articles/s41587-021-00948-x
ミリメートル・スケールの電気治療用生体吸収性光電子システム Millimetre-scale bioresorbable optoelectronic systems for electrotherapy
Yamin Zhang,Eric Rytkin,Liangsong Zeng,Jong Uk Kim,Lichao Tang,Haohui Zhang,Aleksei Mikhailov,Kaiyu Zhao,Yue Wang,Li Ding,Xinyue Lu,Anastasia Lantsova,Elena Aprea,Gengming Jiang,Shupeng Li,Seung Gi Seo,Tong Wang,Jin Wang,Jiayang Liu,Jianyu Gu,Fei Liu,Keith Bailey,Yat Fung Larry Li,Amy Burrell,… John A. Rogers
Nature Published:02 April 2025
DOI:https://doi.org/10.1038/s41586-025-08726-4
Abstract
Temporary pacemakers are essential for the care of patients with short-lived bradycardia in post-operative and other settings. Conventional devices require invasive open-heart surgery or less invasive endovascular surgery, both of which are challenging for paediatric and adult patients. Other complications include risks of infections, lacerations and perforations of the myocardium, and of displacements of external power supplies and control systems. Here we introduce a millimetre-scale bioresorbable optoelectronic system with an onboard power supply and a wireless, optical control mechanism with generalized capabilities in electrotherapy and specific application opportunities in temporary cardiac pacing. The extremely small sizes of these devices enable minimally invasive implantation, including percutaneous injection and endovascular delivery. Experimental studies demonstrate effective pacing in mouse, rat, porcine, canine and human cardiac models at both single-site and multi-site locations. Pairing with a skin-interfaced wireless device allows autonomous, closed-loop operation upon detection of arrhythmias. Further work illustrates opportunities in combining these miniaturized devices with other medical implants, with an example of arrays of pacemakers for individual or collective use on the frames of transcatheter aortic valve replacement systems, to provide unique solutions that address risks for atrioventricular block following surgeries. This base technology can be readily adapted for a broad range of additional applications in electrotherapy, such as nerve and bone regeneration, wound therapy and pain management.
リード線もバッテリーもない、完全植え込み可能な生体吸収性心臓ペースメーカー Fully implantable and bioresorbable cardiac pacemakers without leads or batteries
Yeon Sik Choi,Rose T. Yin,Anna Pfenniger,Jahyun Koo,Raudel Avila,K. Benjamin Lee,Sheena W. Chen,Geumbee Lee,Gang Li,Yun Qiao,Alejandro Murillo-Berlioz,Alexi Kiss,Shuling Han,Seung Min Lee,Chenhang Li,Zhaoqian Xie,Yu-Yu Chen,Amy Burrell,Beth Geist,Hyoyoung Jeong,Joohee Kim,Hong-Joon Yoon,Anthony Banks,Seung-Kyun Kang,… John A. Rogers
Nature Biotechnology Published:28 June 2021
DOIh:ttps://doi.org/10.1038/s41587-021-00948-x
Abstract
Temporary cardiac pacemakers used in periods of need during surgical recovery involve percutaneous leads and externalized hardware that carry risks of infection, constrain patient mobility and may damage the heart during lead removal. Here we report a leadless, battery-free, fully implantable cardiac pacemaker for postoperative control of cardiac rate and rhythm that undergoes complete dissolution and clearance by natural biological processes after a defined operating timeframe. We show that these devices provide effective pacing of hearts of various sizes in mouse, rat, rabbit, canine and human cardiac models, with tailored geometries and operation timescales, powered by wireless energy transfer. This approach overcomes key disadvantages of traditional temporary pacing devices and may serve as the basis for the next generation of postoperative temporary pacing technology.
