2025-05-02 京都大学
非ヒト霊長類の季節の遺伝子発現地図のウェブデータベース
<関連情報>
- https://www.kyoto-u.ac.jp/ja/research-news/2025-05-02
- https://www.kyoto-u.ac.jp/sites/default/files/2025-05/web_2505_Imai-ff7fcd9f87df01d6af0149c422b386e4.pdf
- https://www.nature.com/articles/s41467-025-57994-1
ヒト以外の霊長類の季節的トランスクリプトームアトラスから、生理学と疾患における季節的変化が明らかになる Non-human primate seasonal transcriptome atlas reveals seasonal changes in physiology and diseases
Junfeng Chen,Kousuke Okimura,Liang Ren,Yusuke Nakane,Tomoya Nakayama,Yang Chen,Kai Fukawa,Soutarou Sugiyama,Takayoshi Natsume,Naoko Suda-Hashimoto,Mayumi Morimoto,Takako Miyabe-Nishiwaki,Takao Oishi,Yuma Katada,Manhui Zhang,Kohei Kobayashi,Shoko Matsumoto,Taiki Yamaguchi,Ying-Jey Guh,Issey Takahashi,Taeko Nishiwaki-Ohkawa,Daiki X. Sato,Yoshiharu Murata,Kenta Sumiyama,… Takashi Yoshimura
Nature Communications Published:28 April 2025
DOI:https://doi.org/10.1038/s41467-025-57994-1
Abstract
The metabolic, immune, and endocrine systems show profound seasonal changes in animals, including humans. In addition, morbidity from cardiovascular and psychiatric diseases is more severe and mortality rate is higher in winter. However, their molecular mechanisms remain unknown. Here we report the seasonal transcriptome of 80 tissues collected over 1 year from male and female rhesus macaques kept in a semi-natural outdoor environment. We find seasonal changes in plasma metabolites and hormones. Transcriptome analysis identifies sex differences in seasonally oscillating genes (SOGs) in all tissues studied, and we generate the web database ‘Non-Human Primate Seasonal Transcriptome Atlas (NHPSTA).’ Transcriptional regulatory network analysis, siRNA knockdown, and mutant mouse analyses reveal regulation of SOGs by GA-binding protein (GABP). We also demonstrate seasonal oscillations in the expression of disease risk factor genes and drug interacting genes. NHPSTA provides a molecular resource for seasonally regulated physiology and targets for therapeutic interventions for seasonally regulated diseases.
