2025-09-01 コペンハーゲン大学(UCPH)
<関連情報>
- https://news.ku.dk/all_news/2025/09/ultra-processed-foods-harm-mens-health/
- https://www.cell.com/cell-metabolism/fulltext/S1550-4131(25)00360-2
超加工食品摂取が男性の生殖機能と代謝健康に及ぼす影響 Effect of ultra-processed food consumption on male reproductive and metabolic health
Jessica M. Preston ∙ Jo Iversen ∙ Antonia Hufnagel ∙ … ∙ Marcelo A. Nóbrega ∙ Stephen J. Simpson ∙ Romain Barrès
Cell Metabolism Published:August 28, 2025
DOI:https://doi.org/10.1016/j.cmet.2025.08.004
Graphical abstract
Highlights
- Compared with an unprocessed diet, UPF impaired cardiometabolic and reproductive health
- The deleterious effects of a UPF diet were independent of total caloric intake
- A UPF diet altered the balance of several hormones, including GDF-15 and FSH
- A UPF diet was associated with higher serum concentration of the phthalate cxMINP
Summary
Consumption of ultra-processed food is associated with increased caloric intake and impaired health. Here, we conducted a nutrition trial (NCT05368194) with controlled, 2 × 2 crossover design and tested whether ultra-processed food impairs reproductive and metabolic fitness, with further aggravation by excess caloric intake. Comparing the response from an unprocessed to ultra-processed diet identified increased body weight and low-density lipoprotein (LDL):high-density lipoprotein (HDL) ratio, independent of caloric load. Several hormones involved in energy metabolism and spermatogenesis were affected, including decreased levels of growth/differentiation factor 15 and follicle-stimulating hormone. Sperm quality trended toward impairment, with a decrease in total motility. Differential accumulation of pollutants between the discordant diets were detected, such as decreased plasma lithium and a trend for increased levels of the phthalate mono(4-methyl-7-carboxyheptyl)phthalate (cxMINP) in serum, following the ultra-processed diet. Alteration in caloric load alone had distinct effects on the measured outcomes. This study provides evidence that consumption of ultra-processed food is detrimental for cardiometabolic and reproductive outcomes, regardless of excessive caloric intake.
