2025-11-11 理化学研究所
視覚弁別学習に伴う4ヘルツリズムを介した後部線条体と視覚領域の同期性増強
<関連情報>
- https://www.riken.jp/press/2025/20251111_3/index.html
- https://www.cell.com/iscience/fulltext/S2589-0042(25)02219-9
- https://www.cell.com/iscience/pdf/S2589-0042(25)02219-9.pdf
後線条体、外側膝状体、視覚皮質における学習依存性4Hz同期 Learning-dependent 4 Hz synchronization in the posterior striatum, lateral geniculate nucleus, and visual cortex
Sai Tanimoto ∙ Shigeyoshi Fujisawa
iScience Published:November 6, 2025
DOI:https://doi.org/10.1016/j.isci.2025.113958
Highlights
- The posterior striatum (pStr) changes activity patterns with visual learning
- Learning enhances 4 Hz synchronization between the pStr and visual areas
- The enhanced 4 Hz synchronization is specific to the task phase
- Learning increases the proportion of the pStr neurons phase-locked to 4 Hz
SUMMARY
The posterior striatum (pStr) is thought to play a crucial role in perceptual learning by maintaining stable sensory representations based on past experience and associating them with appropriate motor responses. However, how the pStr neuronal activity acquires these representations, in particular the functional significance of the interactions between the pStr and its sensory input regions, remains largely unexplored. Here, we conducted simultaneous and chronic electrophysiological recordings from the pStr, dorsolateral geniculate nucleus, and visual cortex in rats performing a visual discrimination task. We found that learning enhanced 4 Hz synchronization between the pStr and visual areas, especially during decision-making periods. Moreover, following learning, regular-spiking neurons in the pStr exhibited increased firing rates and stronger phase-locking to these oscillations. These results highlight the involvement of the pStr in visual perceptual learning and indicate the role of 4 Hz oscillations within sensory-striatal circuits in facilitating sensorimotor integration required for efficient task performance.
