2026-03-09 ワシントン大学セントルイス校
＜関連情報＞
- https://source.washu.edu/2026/03/tracking-single-red-blood-cells-as-they-move-through-the-brain/
- https://engineering.washu.edu/news/2026/Functional-photoacoustic-microscopy-reaches-super-resolution-by-tracking-red-blood-cells.html
- https://www.nature.com/articles/s41377-026-02235-3
ラベルフリー細胞追跡による超解像機能的光音響顕微鏡 Super-resolution functional photoacoustic microscopy via label-free cell tracking
Fenghe Zhong,Zhuoying Wang,Youngseop Lee,Jiaxiao Han,Naidi Sun,Shuo Yang,Shengyun Ji,Hao F. Zhang,Cheng Sun & Song Hu
Light: Science & Applications Published:03 March 2026
DOI:https://doi.org/10.1038/s41377-026-02235-3
Abstract
Microvascular function and oxygen metabolism are central to tissue and organ health. However, label-free methods for imaging oxygen dynamics in three-dimensional (3D) microvascular networks at the level of single red blood cells (RBCs)—the fundamental units of oxygen transport in vivo—remain lacking. Here, we introduce super-resolution functional photoacoustic microscopy (SR-fPAM), which spatiotemporally tracks RBC movements under dual-wavelength excitation. SR-fPAM reconstructs super-resolved 3D microvascular architecture comparable to two-photon microscopy while providing quantitative measurements of RBC flow and oxygenation. In live mice, SR-fPAM revealed redistribution of oxygen and hemodynamics across 3D microvascular networks following a single-vessel stroke. These findings establish SR-fPAM as an enabling tool that bridges a critical gap in oxygen-metabolism imaging and opens new avenues for studying microvascular health and disease with unprecedented functional insights.
