目だけで見るのではない:覚醒度が知覚に影響する(Seeing not just with the eyes: degree of arousal affects perception)

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2024-05-15 ミュンヘン大学(LMU)

ミュンヘン大学のローラ・ブッセ教授の研究チームは、視覚情報処理における覚醒状態の影響を研究しました。覚醒度は瞳孔径で示され、覚醒度が高いと瞳孔が大きくなります。チームは視床の電気活動と瞳孔の動態を比較し、覚醒度が視床ニューロンの活動パターンに影響を与えることを発見しました。具体的には、覚醒度に応じてバースト発火とトニック発火のモードが視床核で使われ、これが視覚情報の伝達を調整します。この研究は、視覚認識が覚醒状態によってどのように影響されるかのメカニズムを初めて示すものであり、覚醒依存の調整が複数の時間スケールで行われることを示唆しています。

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視覚視床のスパイキング活動は時間スケールで瞳孔のダイナミクスと連関する Spiking activity in the visual thalamus is coupled to pupil dynamics across temporal scales

Davide Crombie,Martin A. Spacek,Christian Leibold ,Laura Busse
PLOS Biology
  Published: May 14, 2024
DOI:https://doi.org/10.1371/journal.pbio.3002614

目だけで見るのではない:覚醒度が知覚に影響する(Seeing not just with the eyes: degree of arousal affects perception)

Abstract

The processing of sensory information, even at early stages, is influenced by the internal state of the animal. Internal states, such as arousal, are often characterized by relating neural activity to a single “level” of arousal, defined by a behavioral indicator such as pupil size. In this study, we expand the understanding of arousal-related modulations in sensory systems by uncovering multiple timescales of pupil dynamics and their relationship to neural activity. Specifically, we observed a robust coupling between spiking activity in the mouse dorsolateral geniculate nucleus (dLGN) of the thalamus and pupil dynamics across timescales spanning a few seconds to several minutes. Throughout all these timescales, 2 distinct spiking modes—individual tonic spikes and tightly clustered bursts of spikes—preferred opposite phases of pupil dynamics. This multi-scale coupling reveals modulations distinct from those captured by pupil size per se, locomotion, and eye movements. Furthermore, coupling persisted even during viewing of a naturalistic movie, where it contributed to differences in the encoding of visual information. We conclude that dLGN spiking activity is under the simultaneous influence of multiple arousal-related processes associated with pupil dynamics occurring over a broad range of timescales.

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