2026-03-18 早稲田大学
図：圧力制御可能なナノ注射器による細胞内液・ミトコンドリア移送技術
＜関連情報＞
- https://www.waseda.jp/inst/research/news/83718
- https://onlinelibrary.wiley.com/doi/10.1002/smsc.202500598
細胞質輸送とミトコンドリア機能向上を目的としたナノチューブインジェクター A Nanotube Injector for Cytoplasmic Transfer and Enhanced Mitochondrial Function
Bingfu Liu, Zhuhang Dai, Bowen Zhang, Kazuhiro Oyama, Chenxi Li, Yukun Chen, Mingyin Cui, Takeo Miyake
Small Science Published: 17 March 2026
DOI:https://doi.org/10.1002/smsc.202500598
Abstract
The intercellular transportation of molecules is crucial for regulating cell communication and function. However, the existing techniques for molecule transfer across cell barriers often cause cellular damage or have low transfer efficiencies. To address these limitations, this study proposes an innovative nanotube membrane-based injector (nanoinjector) system capable of extracting diverse cytoplasmic molecules from source cells and transferring them to target cells. The developed system demonstrates high efficiency, with over 95% viability and 90% transfer efficiency. Additionally, it enables mitochondrial transfer, which enhances cellular adenosine triphosphate (ATP) production by up to 25% within 24 h. This study explores the impact of intracellular content transport, enabled by this new tool, on cellular activities, with promising implications for cell surgery and therapy.
