2026-06-11 オックスフォード大学
＜関連情報＞
- https://www.ox.ac.uk/news/2026-06-10-decades-old-puzzle-solved-as-scientists-uncover-cause-of-inflammatory-bowel-disease
- https://www.nejm.org/doi/full/10.1056/NEJMoa2513654
炎症性腸疾患におけるインターロイキン-10自己抗体とHLA-DRB1*01:03 Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease
Nima Gharahdaghi, Ph.D., Pai-Jui Yeh, M.D., Lourdes Ceron-Gutierrez, M.Sc., Helen Griffin, Ph.D., Hannah Gordon, Ph.D., M.B., B.S., Chamara Jayamanne, M.D., Alice Fracchia, M.Sc., +42 , and Holm H. Uhlig, D.Phil.
New England Journal of Medicine Published: June 10, 2026
DOI: 10.1056/NEJMoa2513654
Abstract
Background
Neutralizing autoantibodies against interleukin-10 can result in a phenocopy of monogenic defects of interleukin-10 signaling in children and may be associated with inflammatory bowel disease (IBD). The allele HLA-DRB1*01:03 is the strongest genetic risk factor for ulcerative colitis.
Methods
We used a cellular interleukin-10 reporter assay and a confirmatory competitive enzyme-linked immunosorbent assay to assess neutralizing interleukin-10 autoantibodies in serum samples obtained from patients with IBD in the Oxford and U.K. IBD BioResource cohorts and from persons without IBD (controls). An in vitro cytokine-release bioassay was performed in a subgroup of patients to assess interleukin-10, interleukin-23, interleukin-1β, tumor necrosis factor, and interleukin-6. We performed HLA association analysis using imputation and high-resolution sequencing.
Results
Interleukin-10–neutralizing autoantibodies were detected in 173 of 4909 patients with IBD (3.5%; 95% confidence interval [CI], 3.0 to 4.1) and in none of 1006 controls (P<0.001). High anti–interleukin-10 activity in serum was associated with a reduction in detectable interleukin-10 and with an exaggerated proinflammatory cytokine response, consistent with functional neutralization of interleukin-10 signaling. Anti–interleukin-10 seropositivity was strongly associated with HLA-DRB1*01:03 on the basis of imputed data from the Oxford cohort (odds ratio, 50.0; 95% CI, 16.4 to 152.3; P=6.14×10−12) and the U.K. IBD BioResource cohort (odds ratio, 24.7; 95% CI, 14.5 to 42.1; P=6.20×10−32) and in a high-resolution sequencing analysis of data from the Oxford cohort (odds ratio, 29.5; 95% CI, 12.2 to 71.1; P=4.85×10−14).
Conclusions
Neutralizing interleukin-10 autoantibodies were present in a subgroup of patients with IBD and were strongly associated with HLA-DRB1*01:03. (Funded by the National Institute for Health and Care Research and others.)
