新しい論文では、スキンケア製品に添加することで、有害な鉄分を吸収し、日焼けによるダメージを軽減する抗酸化物質が特定されています。 A new paper identifies antioxidants that can be added to skin-care products to mop-up harmful iron, thereby lessening sun damage.
2022-04-12 バース大学
・バース大学で行われた日焼けによる肌の老化に関する新しい研究の結果であり、Antioxidant誌に発表されたもの。
<関連情報>
- https://www.bath.ac.uk/announcements/add-iron-trapping-extracts-to-sunscreens-to-make-them-truly-effective/
- https://www.mdpi.com/2076-3921/11/3/471
肌の老化、鉄とレドックスの恒常性、天然の抗酸化物質について新たな光を放つ Shedding a New Light on Skin Aging, Iron- and Redox-Homeostasis and Emerging Natural Antioxidants
Charareh Pourzand,Andrea Albieri-Borges and Nico N. Raczek
Antioxidant Published: 27 February 2022
DOI:https://doi.org/10.3390/antiox11030471
Abstract
Reactive oxygen species (ROS) are necessary for normal cell signaling and the antimicrobial defense of the skin. However excess production of ROS can disrupt the cellular redox balance and overwhelm the cellular antioxidant (AO) capacity, leading to oxidative stress. In the skin, oxidative stress plays a key role in driving both extrinsic and intrinsic aging. Sunlight exposure has also been a major contributor to extrinsic photoaging of the skin as its oxidising components disrupt both redox- and iron-homeostasis, promoting oxidative damage to skin cells and tissue constituents. Upon oxidative insults, the interplay between excess accumulation of ROS and redox-active labile iron (LI) and its detrimental consequences to the skin are often overlooked. In this review we have revisited the oxidative mechanisms underlying skin damage and aging by focussing on the concerted action of ROS and redox-active LI in the initiation and progression of intrinsic and extrinsic skin aging processes. Based on these, we propose to redefine the selection criteria for skin antiaging and photoprotective ingredients to include natural antioxidants (AOs) exhibiting robust redox–balancing and/or iron-chelating properties. This would promote the concept of natural-based or bio-inspired bifunctional anti-aging and photoprotective ingredients for skincare and sunscreen formulations with both AO and iron-chelating properties.
