発達の乱れにより、精神疾患や薬物乱用への脆弱性が高まる Disrupted development increases vulnerability to mental illness, substance abuse
感情脳回路の成熟の原理 Principles of emotional brain circuit maturation
MATTHEW T. BIRNIE AND TALLIE Z. BARAM
Science Published:2 Jun 2022
The mammalian brain is organized in overlapping, intercalated circuits, and an extensive body of information has focused on the maturation of sensory (visual, auditory) and motor circuits (1–3). Yet, much less is known about the maturation principles of “emotional” brain circuits, including those governing reward-, stress-, and fear-related behaviors. Evidence suggests that sensory inputs from the environment during a sensitive period in early postnatal life have important effects on emotional circuit development, just as adverse or positive images, odors, and sounds influence feelings and actions in adulthood. Disrupted operation of emotional circuits underlies mental illnesses and substance use disorders. Therefore, enhanced recognition of the principles guiding the development of these circuits is important for understanding human health.