一杯のお茶がCOVIDを遠ざける?(Can a cup of tea keep COVID away?)

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2024-03-27 ジョージア大学 (UGA)

ジョージア大学の研究チームが、お茶がCOVID-19に対抗するのに役立つ可能性があることを示唆している。特定のお茶が唾液中のSARS-CoV-2を99.9%まで無効化することが分かり、口腔内でウイルスを無力化することで下部呼吸器系へのウイルス導入を減少させる効果が期待される。臨床試験が必要だが、お茶は医療ケアの補完として有望であり、簡易的な予防手段としても検討されるべきだ。

<関連情報>

唾液中の感染性SARS-CoV-2を迅速に不活化する市販茶のスクリーニング Screening Commercial Tea for Rapid Inactivation of Infectious SARS-CoV-2 in Saliva

Julianna N. Morris & Malak A. Esseili
Food and Environmental Virology  Published:31 January 2024
DOI:https://doi.org/10.1007/s12560-023-09581-0

一杯のお茶がCOVIDを遠ざける?(Can a cup of tea keep COVID away?)

Abstract

SARS-CoV-2 infects the oral mucosa and is shed in salivary fluids. Traditionally, tea has been used by various cultures to treat respiratory ailments. The objective of this study was to identify commercially available teas that can rapidly inactivate infectious SARS-CoV-2 in saliva. Initially, tea (n = 24) was prepared as 40 mg/mL infusions and incubated with SARS-CoV-2 resuspended in water, for 5 min at 37 °C. Then, five teas that showed >3 log reduction in virus infectivity were further investigated at 40 and 10 mg/mL infusions for 60 and 10 s contact time with SARS-CoV-2 resuspended in saliva. Tea polyphenols were measured using the Folin-Ciocalteu assay. SARS-CoV-2 infectivity was quantified on Vero-E6 cell line using TCID50 assay. At 10 mg/mL infusion, black tea showed the highest reduction (3 log, i.e., 99.9%) of infectious SARS-CoV-2 within 10 s. Green, mint medley, eucalyptus-mint, and raspberry zinger teas showed similar inactivation of SARS-CoV-2 (1.5–2 log, i.e., 96–99% reduction). At 40 mg/mL infusions, all five teas showed >3 log reduction in virus infectivity within 10 s. Tea polyphenol but not pH was significantly correlated to virus reduction. Time-of-addition assay revealed that the five teas displayed preventive effects (0.5–1 log, i.e., 68–90% reduction) against SARS-CoV-2 infection of Vero-E6 cells as well as during post-virus infection (1.2–1.9 log, i.e., 94–98%). However, the highest inhibitory effect was observed when the teas were added at the time of virus infection (2–3 log, i.e., 99–99.9%). Our results provide insights into a rapid at-home intervention (tea drinking or gargling) to reduce infectious SARS-CoV-2 load in the oral cavity which might also mitigate infection of the oral mucosa.

医療・健康
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