2026-05-22 韓国基礎科学研究院（IBS）
＜関連情報＞
- https://www.ibs.re.kr/cop/bbs/BBSMSTR_000000000738/selectBoardArticle.do?nttId=26706&pageIndex=1&searchCnd=&searchWrd=
- https://www.science.org/doi/10.1126/science.adv3355
必須アミノ酸欠乏に対する神経系およびホルモン系の腸脳反応の複雑な相互作用 Complex interplay of neuronal and hormonal gut-brain responses to essential amino acid deficit
Boram Kim, Seongju Lee, Hyeyeon Bae, Shinhye Kim, […] , and Greg S. B. Suh
Science Published:21 May 2026
DOI:https://doi.org/10.1126/science.adv3355
Protein deprivation triggers gut cells to release the peptide CNMa to activate CNMaR+ enteric neurons, initiating gut-brain communication in Drosophila.
Abstract
A deficit in dietary protein elicits a nutrient-specific appetite, yet the underlying mechanisms remain poorly understood. In this work, we identify coordinated neuronal and systemic mechanisms in Drosophila that drive an essential amino acid (EAA)–specific appetite. EAA deprivation increases neuropeptide CNMamide (CNMa) expression in gut enterocytes, activating enteric neurons and ellipsoid body neurons in the brain to promote EAA intake through two complementary pathways: a rapid neuronal gut-brain axis and a slower hormonal route. CNMa suppresses the activity of sugar-sensing diuretic hormone 44 (DH44) neurons, thereby reducing carbohydrate intake and biasing feeding toward EAAs. Similarly, protein deprivation in mice promotes an EAA-specific appetite independently of fibroblast growth factor 21 (FGF21). Together, these findings reveal multilayered gut-brain mechanisms that regulate nutrient-specific feeding and maintain EAA homeostasis across species.
