細胞レベルの解像度を持つ初のヒト卵巣のアトラスは人工卵巣への一歩となる(First atlas of the human ovary with cell-level resolution is a step toward artificial ovary)

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2024-04-05 ミシガン大学

ミシガン大学の研究者によると、人間の卵巣に関する新しい「地図」は、卵巣ホルモン産生の回復や生物学的に関連した子供を持つ能力につながる治療法を提案します。この研究により、化学療法や放射線療法などの治療前に保存された組織を使用して人工卵巣を作成する可能性が浮上しました。これにより、長期間の妊娠可能性やホルモン生産が見込まれます。

<関連情報>

形態誘導空間トランスクリプトミクスとシングルセルシーケンスを用いたヒト卵巣の細胞アトラス Cellular atlas of the human ovary using morphologically guided spatial transcriptomics and single-cell sequencing

ANDREA S. K. JONES, D. FORD HANNUM, JORDAN H. MACHLIN, ANSEN TAN, […], AND ARIELLA SHIKANOV
Science Advances Published:5 Apr 2024
DOI:https://doi.org/10.1126/sciadv.adm7506

細胞レベルの解像度を持つ初のヒト卵巣のアトラスは人工卵巣への一歩となる(First atlas of the human ovary with cell-level resolution is a step toward artificial ovary)

Abstract

The reproductive and endocrine functions of the ovary involve spatially defined interactions among specialized cell populations. Despite the ovary’s importance in fertility and endocrine health, functional attributes of ovarian cells are largely uncharacterized. Here, we profiled >18,000 genes in 257 regions from the ovaries of two premenopausal donors to examine the functional units in the ovary. We also generated single-cell RNA sequencing data for 21,198 cells from three additional donors and identified four major cell types and four immune cell subtypes. Custom selection of sampling areas revealed distinct gene activities for oocytes, theca, and granulosa cells. These data contributed panels of oocyte-, theca-, and granulosa-specific genes, thus expanding the knowledge of molecular programs driving follicle development. Serial samples around oocytes and across the cortex and medulla uncovered previously unappreciated variation of hormone and extracellular matrix remodeling activities. This combined spatial and single-cell atlas serves as a resource for future studies of rare cells and pathological states in the ovary.

細胞遺伝子工学
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