2024-08-23 ワシントン大学セントルイス校
A collaborative investigation among WashU Medicine experts in Alzheimer’s disease and multiple sclerosis (MS) finds evidence that MS patients are less likely to have amyloid plaques, a hallmark of Alzheimer’s disease, than adults without MS. (Photo: Getty Images)
<関連情報>
- https://source.washu.edu/2024/08/multiple-sclerosis-appears-to-protect-against-alzheimers-disease/
- https://onlinelibrary.wiley.com/doi/10.1002/ana.27027
多発性硬化症患者におけるアミロイドβ病理の予想外の低率 Unexpected Low Rate of Amyloid-β Pathology in Multiple Sclerosis Patients
Matthew R. Brier MD, PhD, Suzanne E. Schindler, Amber Salter, Dana Perantie, Nicole Shelley, Bradley Judge, Sarah Keefe, Kristopher M. Kirmess, Philip B. Verghese PhD …
Annals of Neurology Published: 04 July 2024
DOI:https://doi.org/10.1002/ana.27027
Abstract
The life expectancy of people with multiple sclerosis (MS) has increased, yet we have noted that development of a typical Alzheimer disease dementia syndrome is uncommon. We hypothesized that Alzheimer disease pathology is uncommon in MS patients. In 100 MS patients, the rate of amyloid-β plasma biomarker positivity was approximately half the rate in 300 non-MS controls matched on age, sex, apolipoprotein E proteotype, and cognitive status. Interestingly, most MS patients who did have amyloid-β pathology had features atypical for MS at diagnosis. These results support that MS is associated with reduced Alzheimer disease risk, and suggest new avenues of research. ANN NEUROL 2024;96:453–459
