2025-06-19 ミシガン大学
<関連情報>
- https://news.umich.edu/hivs-route-to-infection-is-more-flexible-than-previously-believed-u-m-study-finds/
- https://www.science.org/doi/10.1126/sciadv.adn6796
HIV-1はダイニンに直接結合して微小管輸送装置をハイジャックする HIV-1 binds dynein directly to hijack microtubule transport machinery
Somayesadat Badieyan, Drew Lichon, Sevnur Komurlu Keceli, Michael P. Andreas, […] , and Michael A. Cianfrocco
Science Advances Published:18 Jun 2025
DOI:https://doi.org/10.1126/sciadv.adn6796
Abstract
HIV-1 uses the microtubule cytoskeleton to reach the host cell nucleus during replication, yet the molecular basis for microtubule-dependent HIV-1 motility is poorly understood. Using in vitro reconstitution biochemistry and single-molecule imaging, we found that HIV-1 binds to the retrograde microtubule-associated motor, dynein, directly and not via a cargo adaptor, as has been previously suggested. The HIV-1 capsid lattice binds to accessory chains on dynein’s tail domain. Further, we demonstrate that multiple dynein motors tethered to rigid cargoes, such as HIV-1 capsids, display reduced motility, distinct from the behavior of multiple motors on membranous cargoes. Our results provide an updated model of HIV-1 trafficking wherein HIV-1 binds to dynein directly to “hijack” the dynein transport machinery for microtubule motility.
