2025-09-11 産業技術総合研究所
<関連情報>
- https://www.aist.go.jp/aist_j/press_release/pr2025/pr20250911/pr20250911.html
- https://advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.202502546
二機能性オルトシリコリン酸塩MgO-CaO-ZnO-P2O5-SiO2ガラスの調製:抗菌活性および骨芽細胞遺伝子発現挙動のin vitro評価 Preparation of Bifunctional Orthosilicophosphate MgO-CaO-ZnO-P2O5-SiO2 Glasses: in vitro Evaluation of Antibacterial Activity and Osteoblast Gene Expression Behavior
Sungho Lee, Hayato Asano, Makoto Sakurai, Takayoshi Nakano, Toshihiro Kasuga
Advanced Healthcare Materials Published: 06 September 2025
DOI:https://doi.org/10.1002/adhm.202502546
Abstract
Phosphate and phosphate invert glasses contain various elements, with a wide range of compositions. Recently, our group reported orthosilicophosphate glasses (SPGs) and the glass network structure composed of orthophosphates and orthosilicates crosslinked by cations. ZnO is an intermediate oxide that improves the chemical durability of glass. Additionally, Zn2+ ions exhibit antibacterial activity and stimulate bone formation. In this work, ZnO-containing SPGs are prepared for biomedical applications. The glasses are mainly composed of PO4, SiO4, MgO4, and ZnO4 orthotetrahedral structures. The ZnO-containing SPGs exhibit excellent antibacterial activity, with bacterial counts > 5 orders of magnitude lower than that of the control. Meanwhile, ZnO-containing SPGs have mild inhibitory effects on cell proliferation by Zn2+ ions; however, they exhibit significant upregulation of osteogenic markers compared with the control owing to the release of inorganic ions from the glasses. The ZnO-containing SPGs prepared in this work exhibit bifunctional properties suitable for biomedical applications. They serve as bioadaptive materials capable of controlling gene expression by releasing therapeutic ions.
