2025-10-10 スウェーデン王立工科大学(KTH)
<関連情報>
- https://www.kth.se/en/om/nyheter/centrala-nyheter/pan-disease-atlas-maps-molecular-fingerprints-of-health-disease-and-aging-1.1430279
- https://www.science.org/doi/10.1126/science.adx2678
循環プロテオームのヒト全疾患血液アトラス A human pan-disease blood atlas of the circulating proteome
María Bueno Álvez, Sofia Bergström, Josefin Kenrick, Emil Johansson, […] , and Mathias Uhlén
Science Published:9 Oct 2025
DOI:https://doi.org/10.1126/science.adx2678
Abstract
The human blood proteome provides a holistic readout of health states through the assessment of thousands of circulating proteins. Here, we present a pan-disease resource to enable the study of diverse disease phenotypes within a harmonized proteomics dataset. By profiling protein concentrations across 59 diseases and healthy cohorts, we identified proteins associated with age, sex, and BMI, as well as disease-specific signatures. This study highlights shared and distinct protein patterns across conditions, demonstrating the power of a unified proteomics approach to uncover biological insights. The dataset, covering 8,262 individuals and up to 5,416 proteins, serves as an online resource for exploring disease-specific protein profiles and advancing precision medicine research.
