2025-12-02 東京大学
<関連情報>
- https://www.k.u-tokyo.ac.jp/information/category/press/0028586.html
- https://www.k.u-tokyo.ac.jp/assets/files/ヒトから海洋・土壌までウイルスの多様性を包括的に解析するデータベースVIREを構築_WEB.pdf
- https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkaf1225/8356007
VIRE: 環境的コンテキストを備えたメタゲノム由来の惑星規模のウイルスリソース VIRE: a metagenome-derived, planetary-scale virome resource with environmental context
Suguru Nishijima ,Anthony Fullam ,Thomas S B Schmidt ,Michael Kuhn ,Peer Bork
Nucleic Acids Research Published:29 November 2025
DOI:https://doi.org/10.1093/nar/gkaf1225
Abstract
Viruses are the most abundant biological entities on Earth, yet their global diversity remains largely unexplored. Here, we present VIRE, a comprehensive resource comprising over 1.7 million high- and medium-quality viral genomes recovered from >100 000 publicly available metagenomes derived from samples that cover diverse ecosystems, including host-associated, aquatic, terrestrial, and anthropogenic environments. Using a unified and scalable pipeline, we systematically assembled viral genomes and provided detailed information on genome completeness, taxonomic classification, predicted lifestyle, and host assignment based on CRISPR spacer matches. VIRE contains >89 million predicted viral open reading frames, as well as detailed functional annotations derived from multiple databases. Importantly, VIRE is seamlessly integrated with related microbiome resources such as SPIRE (https://spire.embl.de) and Metalog (https://metalog.embl.de), enabling users to jointly explore viral genomes, metagenome-assembled genomes, and associated environmental or clinical metadata. Accessible at https://vire.embl.de, VIRE provides an open-access, scalable platform for investigating viral diversity, evolution, and ecology on a planetary scale.
