2026-03-25 ラトガース大学
＜関連情報＞
- https://www.rutgers.edu/news/research-sheds-light-potential-causes-infertility
- https://insight.jci.org/articles/view/195254
ヒト子宮内膜および脱落膜の単一細胞マッピングにより、生殖能力に対する上皮細胞と間質細胞の寄与が明らかになった Single-cell mapping of human endometrium and decidua reveals epithelial and stromal contributions to fertility
Gregory W. Burns, Emmanuel N. Paul, Manisha Persaud, Qingshi Zhao, Rong Li, Kristin Blackledge, Jessica Garcia de Paredes, Pratibha Shukla, Ripla Arora, Anat Chemerinski, and Nataki C. Douglas
JCI Insight Published: January 23, 2026
DOI:https://doi.org/10.1172/jci.insight.195254
Abstract
The human endometrium undergoes dynamic changes across the menstrual cycle to establish a receptive state for embryo implantation. Using bulk and single-cell RNA-Seq, we characterized gene expression dynamics in the cycling endometrium and the decidua from early pregnancy. We demonstrated that during the mid-secretory phase — the period encompassing the window of implantation — secretory glandular epithelial cells undergo notable transcriptional changes and alterations in cell-cell communication. Through comprehensive analyses, we identified the glandular epithelium receptivity module (GERM) signature, comprising 556 genes associated with endometrial receptivity. This GERM signature was consistently perturbed across datasets of endometrial samples from women with impaired fertility, validating its relevance as a marker of receptivity. In addition to epithelial changes, we observed shifts in stromal cell populations, notably involving decidual and senescent subsets, which also play key roles in modulating implantation. Together, these findings provide a high-resolution transcriptomic atlas of the receptive and early pregnant endometrium and shed light on key molecular pathways underlying successful implantation.
