小児ARFIDに有効な2種類の治療法を確認(Study Finds Two Effective ARFID Treatments for Kids)

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2026-06-29 スタンフォード大学

スタンフォード大学医学部の研究チームは、小児の回避・制限性食物摂取症(ARFID)に対する世界初の無作為化比較試験を実施し、家族ベース療法(FBT)と個人ベース療法(CBT-AR)の有効性を比較した。ARFIDは体型へのこだわりではなく、食べ物への興味の低さや味・食感への過敏性、窒息への恐怖などから食事量や食品の種類が著しく制限される摂食障害で、子どもの成長や栄養状態に悪影響を及ぼす。6~12歳の98人を対象とした試験では、両治療法とも摂取できる食品の種類を有意に増やし、症状の改善が認められた。一方、家族ベース療法では保護者が食事支援に積極的に関与することで、体重増加や栄養状態の改善にもより高い効果が確認された。本研究は、ARFIDに対する初めての十分な科学的根拠を提供し、年齢や症状に応じた治療法の選択や標準的な診療指針の整備に重要な知見をもたらす成果となった。

<関連情報>

回避性・制限性食物摂取障害を持つ子供に対する家族療法と個別療法の比較:ランダム化臨床試験 Family vs Individual Treatment for Children With Avoidant/Restrictive Food Intake Disorder: A Randomized Clinical Trial

James Lock, MD, PhD ∙ Brittany Matheson, PhD ∙ Booil Jo, PhD ∙ … ∙ Hazal Y. Gurcan, BA ∙ Ainsley E. Cogburn, BS ∙ Bohye Kim, MS
Journal of the American Academy of Child & Adolescent Psychiatry  Published:April 20, 2026
DOI:https://doi.org/10.1016/j.jaac.2026.04.007

小児ARFIDに有効な2種類の治療法を確認(Study Finds Two Effective ARFID Treatments for Kids)

ABSTRACT

Objective

To examine the comparative efficacy of Family-based Treatment for Avoidant/Restrictive Food Intake Disorder (FBT-ARFID) to individual Psychoeducational Motivational Therapy (PMT) for underweight children with ARFID between the ages of 6 and 12 years of age. The main outcome evaluated was the difference between groups on change in percent estimated body weight (%EBW) from baseline (BL) to end of treatment (EOT).

Method

Ninety-eight children with ARFID were randomized to 14 sessions over 4 months of telehealth FBT-ARFID or PMT. Assessments of weight/height, eating-related cognitions, and behaviors associated with ARFID were collected online at BL, 1 month, 2 months, and EOT by assessors masked to treatment condition.

Results

FBT-ARFID was superior to PMT at the EOT in promoting increased %EBW. There were no differences between groups on improvements in overall severity of ARFID symptoms or other related ARFID symptoms; however, BL severity of ARFID symptoms moderated the effect, with children who were most symptomatic improving significantly more in FBT-ARFID than in PMT (exploratory analyses).

Conclusion

FBT-ARFID is superior to PMT for promoting weight gain in low-weight children with ARFID, especially for those children with greater severity of ARFID symptoms.

医療・健康
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