2026-08-12 ジョージア大学 (UGA)
＜関連情報＞
- https://news.uga.edu/documenting-seizures/
- https://opg.optica.org/boe/fulltext.cfm?uri=boe-17-8-4216
適応光学ライトシート顕微鏡を用いたゼブラフィッシュ発作モデルの高速体積イメージング Fast volumetric imaging of a zebrafish seizure model with adaptive optics light sheet microscopy
Bingxi Liu, Yang Liu, Carly Duffy, James D. Lauderdale, and Peter Kner
Biomedical Optics Express Published: July 21, 2026
DOI:https://doi.org/10.1364/BOE.596096
Abstract
Light sheet microscopy is a powerful tool for imaging live organisms. To enable high-speed volumetric imaging, we have developed a light sheet system incorporating an electrically tunable lens (ETL) capable of capturing volumes up to 499 × 499 × 150 μm3 at 4 volumes per second with near diffraction-limited resolution. The system employs sensorless adaptive optics to correct ETL induced system aberrations, extending the usable field of view by fivefold. We apply this system to image the propagation of seizures in zebrafish larvae and observe that seizures originate in the posterior brain, propagate anteriorly toward the optic tectum and gradually subside over tens of seconds.
