2026-10-12 ジョンズ・ホプキンス大学（JHU）
＜関連情報＞
- https://hub.jhu.edu/2026/10/12/magnetic-millirobots-cardiac-treatment/
- https://advanced.onlinelibrary.wiley.com/doi/10.1002/admt.71353
磁気駆動式ワイヤレスモジュール型ミリロボットによる心臓標的薬物送達 Wireless Modular Millirobots With Magnetic Actuation for Targeted Cardiac Drug Delivery
Anuruddha Bhattacharjee, Suraj Raval, Xinhao Chen, Adam May, Ayush Saraswat, Chintan Panigrahi, Yash Chadda, Lamar O. Mair, Joseph Katz, …
Advanced Materials Technologies Published: 28 September 2026
DOI:https://doi.org/10.1002/admt.71353
ABSTRACT
Infective endocarditis remains difficult to treat due to limited drug accumulation at infection sites via systemic delivery and reliance on invasive, high-risk surgery. To address this, we present a wireless, modular millirobotic system actuated by external magnetic fields for targeted cardiac drug delivery. We validate the system in vitro using an agarose heart phantom under physiologically relevant pulsatile flow and ex vivo by demonstrating tissue penetration and module undocking in excised porcine heart tissue. The system comprises two cooperative millirobots: a barbed needle module that reduces tissue penetration force by 66.7% in cardiac tissue-mimicking gels, and a drug module capable of delivering 22 microliter liquid doses over 180 min. AI-assisted vision guidance enables autonomous navigation with root-mean-square tracking errors of 0.23 and 0.26 body lengths for the needle and drug modules, respectively. The modules support on-demand magnetic docking and undocking, achieving success rates of 100% and 93%, respectively. These results highlight the potential of modular millirobots for precise, repeatable, and minimally invasive cardiac therapies.
