犬の神経膠腫の診断基準を評価する研究者たち(Researchers Assess Diagnostic Criteria for Canine Glioma)

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2022-08-15 ノースカロライナ州立大学(NCState)

最近発表された犬のグリオーマの診断基準を用いることで、病理医の間で強い診断上のコンセンサスが得られることを明らかにしました。この結果は、犬の脳腫瘍の診断基準をより標準化する道を開いただけでなく、犬や人間の神経膠腫を支援する大規模な施設間研究を支援するための有用な基準値を作成するものです。

<関連情報>

犬の神経膠腫の診断、分類および等級付けに関する病理医間の合意について Inter-pathologist agreement on diagnosis, classification and grading of canine glioma

Gregory A. Krane,Keith R. Shockley,David E. Malarkey,Andrew D. Miller,C. Ryan Miller,Debra A. Tokarz,Heather L. Jensen,Kyathanahalli S. Janardhan,Matthew Breen,Christopher L. Mariani
Veterinary and Comparative Oncology  Published: 20 July 2022
DOI:https://doi.org/10.1111/vco.12853

Abstract

Histopathological evaluation of tumors is a subjective process, but studies of inter-pathologist agreement are uncommon in veterinary medicine. The Comparative Brain Tumour Consortium (CBTC) recently published diagnostic criteria for canine gliomas. Our objective was to assess the degree of inter-pathologist agreement on intracranial canine gliomas, utilising the CBTC diagnostic criteria in a cohort of eighty-five samples from dogs with an archival diagnosis of intracranial glioma. Five pathologists independently reviewed H&E and immunohistochemistry sections and provided a diagnosis and grade. Percentage agreement and kappa statistics were calculated to measure inter-pathologist agreement between pairs and amongst the entire group. A consensus diagnosis of glioma subtype and grade was achieved for 71/85 (84%) cases. For these cases, percentage agreement on combined diagnosis (subtype and grade), subtype only and grade only were 66%, 80% and 82%, respectively. Kappa statistics for the same were 0.466, 0.542 and 0.516, respectively. Kappa statistics for oligodendroglioma, astrocytoma and undefined glioma were 0.585, 0.566 and 0.280 and were 0.516 for both low-grade and high-grade tumors. Kappa statistics amongst pairs of pathologists for combined diagnosis varied from 0.352 to 0.839. 8 % of archival oligodendrogliomas and 61% of archival astrocytomas were reclassified as another entity after review. Inter-pathologist agreement utilising CBTC guidelines for canine glioma was moderate overall but varied from fair to almost perfect between pairs of pathologists. Agreement was similar for oligodendrogliomas and astrocytomas but lower for undefined gliomas. These results are similar to pathologist agreement in human glioma studies and with other tumor entities in veterinary medicine.

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