2023-04-12 スウォンジー大学
この効果が人間でも同様にある場合、自己免疫疾患を患う患者の不適切なT細胞活性化を緩和するために治療薬として使用される可能性がある。ただし、通常のバランスのとれた食事においてスクラロースを消費することによる有害な影響は見られないため、健康的な免疫システムを維持するために食事を変える必要はない。
今後、この発見が人間で再現されるかどうかを確認するための試験が行われる予定である。
<関連情報>
- https://www.swansea.ac.uk/press-office/news-events/news/2023/04/artificial-sweetener-could-dampen-immune-response-to-disease-in-mice.php
- https://www.nature.com/articles/s41586-023-05801-6
食用甘味料スクラロースは、T細胞媒介応答の負のモジュレーターである The dietary sweetener sucralose is a negative modulator of T cell-mediated responses
Fabio Zani,Julianna Blagih,Tim Gruber,Michael D. Buck,Nicholas Jones,Marc Hennequart,Clare L. Newell,Steven E. Pilley,Pablo Soro-Barrio,Gavin Kelly,Nathalie M. Legrave,Eric C. Cheung,Ian S. Gilmore,Alex P. Gould,Cristina Garcia-Caceres &Karen H. Vousden
Nature Published:15 March 2023
DOI:https://doi.org/10.1038/s41586-023-05801-6
Abstract
Artificial sweeteners are used as calorie-free sugar substitutes in many food products and their consumption has increased substantially over the past years1. Although generally regarded as safe, some concerns have been raised about the long-term safety of the consumption of certain sweeteners2,3,4,5. In this study, we show that the intake of high doses of sucralose in mice results in immunomodulatory effects by limiting T cell proliferation and T cell differentiation. Mechanistically, sucralose affects the membrane order of T cells, accompanied by a reduced efficiency of T cell receptor signalling and intracellular calcium mobilization. Mice given sucralose show decreased CD8+ T cell antigen-specific responses in subcutaneous cancer models and bacterial infection models, and reduced T cell function in models of T cell-mediated autoimmunity. Overall, these findings suggest that a high intake of sucralose can dampen T cell-mediated responses, an effect that could be used in therapy to mitigate T cell-dependent autoimmune disorders.
