バイオマテリアルによるワンツーパンチががん免疫療法を後押し(Biomaterial-delivered one-two punch boosts cancer immunotherapy)

2023-07-13 ハーバード大学

<関連資料>

• https://seas.harvard.edu/news/2023/07/biomaterial-delivered-one-two-punch-boosts-cancer-immunotherapy
• https://www.nature.com/articles/s41467-023-39330-7

クライオゲル足場を用いた養子移入T細胞療法と宿主抗原提示細胞リクルートメントにより、固形がんに対する長期的な防御が促進される Adoptive T cell transfer and host antigen-presenting cell recruitment with cryogel scaffolds promotes long-term protection against solid tumors

Kwasi Adu-Berchie,Joshua M. Brockman,Yutong Liu,Tania W. To,David K. Y. Zhang,Alexander J. Najibi,Yoav Binenbaum,Alexander Stafford,Nikolaos Dimitrakakis,Miguel C. Sobral,Maxence O. Dellacherie & David J. Mooney
Nature Communications  Published:15 June 2023
DOI:https://doi.org/10.1038/s41467-023-39330-7

Abstract

Although adoptive T cell therapy provides the T cell pool needed for immediate tumor debulking, the infused T cells generally have a narrow repertoire for antigen recognition and limited ability for long-term protection. Here, we present a hydrogel that locally delivers adoptively transferred T cells to the tumor site while recruiting and activating host antigen-presenting cells with GMCSF or FLT3L and CpG, respectively. T cells alone loaded into these localized cell depots provided significantly better control of subcutaneous B16-F10 tumors than T cells delivered through direct peritumoral injection or intravenous infusion. T cell delivery combined with biomaterial-driven accumulation and activation of host immune cells prolonged the activation of the delivered T cells, minimized host T cell exhaustion, and enabled long-term tumor control. These findings highlight how this integrated approach provide both immediate tumor debulking and long-term protection against solid tumors, including against tumor antigen escape.