2024-12-17 ノースウェスタン大学
Northwestern scientists discovered that hippocampal oscillations occur at particular points in the breathing cycle, suggesting that breathing is a critical rhythm for proper memory consolidation during sleep.
<関連情報>
- https://news.northwestern.edu/stories/2024/12/breathing-coordinates-brain-rhythms-for-memory-consolidation-during-sleep/
- https://www.pnas.org/doi/10.1073/pnas.2405395121
呼吸はヒトの海馬における睡眠振動の同期を組織化する Breathing orchestrates synchronization of sleep oscillations in the human hippocampus
Andrew Sheriff, Guangyu Zhou, Vivek Sagar, +7, and Christina Zelano
Proceedings of the National Academy of Sciences Published:December 16, 2024
DOI:https://doi.org/10.1073/pnas.2405395121
Significance
Here, we suggest a hypothesis in which breathing underlies intrinsic coordination of sleep oscillations in humans. Brain rhythms during sleep coordinate activity across different neural systems, as part of memory consolidation processes. These coordinated sleep oscillations occur throughout non-REM sleep in bursts, and have widely been assumed to emerge intrinsically during sleep with no underlying rhythm or external impetus. Recently, however, sleep oscillations have been shown to coordinate on a slow timescale of about 3 to 6 s. Intriguingly, human breathing rates overlap with this range. Our findings show that human breathing drives a slow hippocampal rhythm during sleep, sleep oscillations in the hippocampus couple to breathing, and respiratory coupling promotes coordination of sleep oscillations, suggesting a role in memory consolidation.
Abstract
Nested sleep oscillations, emerging from asynchronous states in coordinated bursts, are critical for memory consolidation. Whether these bursts emerge intrinsically or from an underlying rhythm is unknown. Here, we show a previously undescribed respiratory-driven oscillation in the human hippocampus that couples with cardinal sleep oscillations. Further, breathing promotes nesting of ripples in slow oscillations, together suggesting that respiration acts as an intrinsic rhythm to coordinate synchronization of sleep oscillations, providing a unique framework to characterize sleep-related respiratory and memory processes.
