MWI排出物への暴露により母乳の汚染物質がわずかに増加することが判明 (Women exposed to MWI emissions show small increase in breast milk pollutants)

2024-12-18 インペリアル・カレッジ・ロンドン (ICL)

<関連情報>

• https://www.imperial.ac.uk/news/259340/women-exposed-mwi-emissions-show-small/
• https://www.sciencedirect.com/science/article/abs/pii/S0013935124024927

英国の都市ごみ焼却場周辺に住む人のヒト乳汁中のポリ塩化ジベンゾダイオキシン/フランおよびポリ塩化ビフェニル濃度: 母乳・環境・初期生活・発達(BEED)ヒトバイオモニタリング調査からの知見 Polychlorinated dibenzo-dioxin/furan and polychlorinated biphenyl concentrations in the human milk of individuals living near municipal waste incinerators in the UK: Findings from the Breast milk, Environment, Early-life, and Development (BEED) human biomonitoring study

Ruth E. Parsons, Philippa Douglas, Danielle Ashworth, Anna L. Hansell, Ovnair Sepai, Marc Chadeau-Hyam, Mireille B. Toledano
Environmental Research  Available online: 8 December 2024
DOI:https://doi.org/10.1016/j.envres.2024.120588

Graphical abstract

Highlights

• The first human biomonitoring study of PCDD/Fs and PCBs in human milk in the UK
• Involved 194 first-time mothers living near 3 Municipal Waste Incinerators (MWIs)
• The study looked at associations of milk contaminants with MWI emissions
• Modelled MWI PM₁₀ was associated with human milk ∑TEQ₂₀₀₅-PCDD/Fs + PCB
• MWI proximity was not associated with human milk ∑TEQ₂₀₀₅-PCDD/Fs + PCB

Abstract

The objective of this study is to report recent PCDD/F and PCB human milk concentrations in the United Kingdom (UK) and relate these to two proxies for exposure to municipal waste incinerator (MWI) emissions.

As part of the Breast milk, Environment, Early-life, and Development (BEED) study, primiparous individuals were recruited from within 20km of English MWIs between 2013 and 2015 and asked to provide human milk samples. The samples were analysed for quantitative concentrations of 17 PCDD/F and 12 PCB congeners. Linear regression models were used to investigate the association between two proxy measurements for exposure to MWI emissions: (i) log average modelled daily ground-level PM₁₀ from MWIs (modelled PM₁₀) and (ii) residential proximity to nearest MWI and the toxic equivalents (TEQs), ∑TEQ₂₀₀₅-PCDD, ∑TEQ₂₀₀₅-PCB and ∑TEQ₂₀₀₅-PCDD/F + PCB.

Samples from 194 participants were analysed for PCDD/Fs and 150 for PCBs. Overall ∑TEQ₂₀₀₅-PCDD/F + PCBs ranged from 1.76 to 25.1pg/g lipid with a geometric mean of 5.81 (Geometric standard deviation: 1.64). A doubling in modelled PM₁₀ was significantly associated with an average increase of 9.71% (95% CI: 2.91% to 16.5%) in ∑TEQ₂₀₀₅-PCDD/Fs + PCB, 9.14% (95% CI: 1.79% to 16.5%) in ∑TEQ₂₀₀₅-PCDD/Fs and 9.02% (CI:1.57% to 16.5%) in ∑TEQ₂₀₀₅-PCBs. MWI proximity was not associated with an increase of ∑TEQ₂₀₀₅-PCDD/Fs, ∑TEQ₂₀₀₅-PCBs, or ∑TEQ₂₀₀₅-PCDD/Fs + PCBs.

The results from this study suggest that MWI emissions may make a small contribution to the body burden of toxic PCDD/F and PCB mixtures. Enhanced environmental monitoring and human biomonitoring of PCDD/Fs and PCBs near MWIs would be needed to investigate this further.