2025-05-27 中国科学院(CAS)
Histone Chaperone-Mediated Replication-Coupled Chromatin Assembly Pathway (Image by XU Ruiming’s Group)
<関連情報>
- https://english.cas.cn/newsroom/research_news/life/202505/t20250528_1044590.shtml
- https://www.sciencedirect.com/science/article/abs/pii/S0959440X25000776?via%3Dihub
複製連関クロマチンアセンブリにおけるヒストンシャペロンの構造と機能
Structure and function of histone chaperones in replication-coupled chromatin assembly
Chao-Pei Liu, Rui-Ming Xu
Current Opinion in Structural Biology Available online: 7 May 2025
DOI:https://doi.org/10.1016/j.sbi.2025.103059
Eukaryotic cell divisions pass on genetic and epigenetic information from parental to daughter cells through replication of the chromatin, which needs to be reestablished following DNA replication, as its building block, the nucleosome, is disrupted by the passage of the DNA replication fork. This replication-coupled (RC) nucleosome assembly process takes place in distinct pathways depending on whether newly synthesized or parental histones are used. This review highlights recent progress in structural and biochemical studies of RC nucleosome assembly, focusing on the roles of histone chaperones in both de novo assembly of nucleosomes from newly synthesized histones and the recycling of parental histones. We also discuss the interactions between histone chaperones and replisome components that govern the coupling of nucleosome assembly to chromatin replication. Finally, we offer our perspective on future efforts in advancing this important research direction.
