粘着性細胞の問題を電気気泡で解決、藻類バイオリアクターなどへ応用(MIT engineers solve sticky cell problem for bioreactors and other industries)

2025-10-15 マサチューセッツ工科大学(MIT)

<関連情報>

• https://news.mit.edu/2025/mit-engineers-solve-sticky-cell-problem-bioreactors-and-other-industries-1015
• https://www.science.org/doi/10.1126/sciadv.adu3708

泡駆動による細胞剥離 Bubble-driven cell detachment

Bert Vandereydt, Baptiste Blanc, and Kripa K. Varanasi
Science Advances  Published:15 Oct 2025
DOI:https://doi.org/10.1126/sciadv.adu3708

Abstract

On-demand cell detachment is of great importance in various applications in biosensitive environments. Existing methods such as enzymatic treatments and mechanical scraping are often time-consuming, labor-intensive, and harmful to cells. In this work, we demonstrate a method of detaching cells from substrates using electrochemical bubble generation without biocide generation. We demonstrate that shear stress generated by fluid flow beneath a rising bubble is the primary mechanism for cell detachment. This strategy, relying solely on physical forces and independent of cell or surface chemistry, can therefore work with a large range of the media, surfaces, and cells. We successfully implement this discovery at the lab-scale by designing a prototype for on-demand cell detachment that maintains high cell viability. The developed principle could find applications in high-throughput culture settings, such as algae photobioreactors or cell culture environments.