2025-11-04 理化学研究所
Web要約 の発言:
人工動原体を微小管の「おとり」にして染色体数異常を抑える卵子老化の克服戦略
<関連情報>
- https://www.riken.jp/press/2025/20251104_1/index.html
- https://www.nature.com/articles/s41556-025-01792-w
卵母細胞における減数分裂エラーを防ぐためのデコイとしてタンパク質ベースの人工動原体を設計する Designing protein-based artificial kinetochores as decoys to prevent meiotic errors in oocytes
Yuanzhuo Zhou,Kohei Asai,Hirohisa Kyogoku & Tomoya S. Kitajima
Nature Cell Biology Published:04 November 2025
DOI:https://doi.org/10.1038/s41556-025-01792-w
Abstract
Chromosome mis-segregation during meiosis in oocytes causes miscarriages and congenital diseases. Ageing-associated premature chromosome separation is a major cause of mis-segregation. Effective prevention of premature chromosome separation has not yet been achieved. Here we design protein-based artificial kinetochores that act as decoys to prevent premature chromosome separation. Designed artificial kinetochore-like decoys are submicroscale clusters of NDC80-NUF2-tethered protein particles that can establish a biorientation-like state by competing with chromosomal kinetochores for HURP-decorated microtubules. This competition reduces excessive bipolar microtubule pulling forces exerted on chromosomes, thereby effectively preventing premature chromosome separation during meiosis I and II in aged mouse oocytes. These effects suppress egg aneuploidy. This study provides a decoy strategy with biocompatible artificial kinetochores to prevent ageing-associated meiotic errors in oocytes.
