2026-06-24 中国科学院（CAS）
＜関連情報＞
- https://english.cas.cn/newsroom/research-news/202606/t20260622_1174423.shtml
- https://www.science.org/doi/10.1126/science.aea2535
ヤツメウナギの3D単一細胞トランスクリプトミクスにより、脊椎動物の脳の祖先的特徴と特殊化特徴が明らかになる Lamprey 3D single-cell transcriptomics reveals ancestral and specialized features of the vertebrate brain
Haixu Wu, Duoyuan Chen, Jun Li, Tao Zhou, […] , and Bing Su
Science Published:18 Jun 2026
DOI:https://doi.org/10.1126/science.aea2535
Three-dimensional transcriptomic atlas of the lamprey brain and vertebrate brain evolution.
Abstract
The lamprey occupies a pivotal position for elucidating vertebrate brain evolution. Using spatial transcriptomics and single-nucleus RNA sequencing, we generated a three-dimensional molecular atlas of the lamprey brain, identifying 209 distinct cell clusters across 14 regions. Cross-species comparisons revealed broad conservation of regional spatial architecture, defining an ancestral organizational blueprint. Within this conserved framework, however, marked lineage-specific divergence emerged. We observed extensive neuronal specialization across vertebrate lineages, accompanied by regulatory shifts associated with spatial reorganization and functional diversification of neuronal populations. Additionally, our results suggest that a cerebellum-like architecture predates the jawed vertebrate cerebellum. Together, these findings identified constraints on neural organization and detected cellular innovations driving evolutionary diversification.
