2026-09-30 バッファロー大学（UB）
Salivary gland organoids, derived from pluripotent stem cells, hold promise for studying salivary gland development, disease progression, and drug screening.
＜関連情報＞
- https://www.buffalo.edu/news/releases/2026/09/Pluripotent-stem-cells-Andreadis-study.html
- https://www.nature.com/articles/s41467-026-77724-5
ヒト多能性幹細胞から機能的かつ移植可能な唾液腺オルガノイドを誘導するための発生学的アプローチ Development-inspired approach for the derivation of functional and transplantable salivary gland organoids from human pluripotent stem cells
Laura J. Sherwood, Ronel Z. Samuel, Sai Harsha Bhamidipati, Kihoon Nam, Frank Maslow, Travis Small, Yali Zhang, Jianmin Wang, Song Liu, Olga J. Baker & Stelios T. Andreadis
Nature Communications Published:17 September 2026
DOI:https://doi.org/10.1038/s41467-026-77724-5 Early provide
Abstract
Salivary gland (SG) hypofunction significantly affects the life quality of patients with hyposalivation. Current treatment options for these conditions are limited and often result in undesirable side effects. To address this issue, we’ve developed a developmentally inspired strategy to derive salivary gland epithelial progenitor (SGEP) cells from human pluripotent stem cells (PSC). Then we employ SGEP cells derived from human PSC with a SOX10::GFP reporter to engineer three-dimensional lumenized SG organoids, with well-defined lumens and secretory function, reminiscent of human salivary glands. Upon transplantation into the submandibular gland of athymic nude mice, mCherry+ salivary gland organoids (SGO) integrate into the gland and differentiated into salivary gland phenotypes, including acinar, ductal and myoepithelial structures. Our findings suggest that SG organoids may hold promise for studying SG development, disease progression and drug screening, as well as for development of cell therapies for salivary gland regeneration.
