2022-03-25 南洋(ナンヤン)理工大学(NTU)
・プロバイオティクスは、尿路や消化管の感染症を予防し、健康な腸内細菌叢を維持することで、肥満のリスクを低減し、健康全般を促進することが分かっています。
・NTUの研究では、プロバイオティクスである腸内細菌の乳酸菌を独自の技術でコーティングし、胃の中の厳しい酸性条件から保護した。
<関連情報>
- https://www.ntu.edu.sg/news/detail/delivering-good-bacteria-into-our-guts
- https://www3.ntu.edu.sg/CorpComms2/Releases/NR2022/NR_220324_probiotics/probiotics.pdf
乳酸菌プロバイオティクスの噴霧乾燥によるその場でのアルギン酸架橋による消化管内標的デリバリーの促進 In situ alginate crosslinking during spray-drying of lactobacilli probiotics promotes gastrointestinal-targeted delivery
Li Ling Tan , Manish Mahotra , Si Ye Chan , Say Chye Joachim Loo ,
published in Carbohydrate Polymers in Feb 2022. DOI 10.1016/j.carbpol.2022.119279
ABSTRACT
Alginate-based formulations have shown desirable functional characteristics for probiotic encapsulation. However, current technologies used to produce these formulations are inefficient, detrimental to probiotics viability or do not produce dry, shelf-stable products. Herein, we developed a novel spray-drying technique that combines particle formation, alginate crosslinking and drying into a single step, thereby streamlining the production of encapsulated probiotics powder. Lacticaseibacillus rhamnosus GG (LGG) encapsulated in six encapsulation formulations were characterized and compared. Among the six formulations investigated, the crosslinked alginate with sucrose formulation (Ca-Alg-Suc) was found to be most promising, achieving ~109 CFU/g of surviving LGG after spray-drying and exposure to simulated gastric fluid (SGF). The Ca-Alg-Suc formulation was further evaluated with Lactiplantibacillus plantarum and Lacticaseibacillus paracasei, and similar results of high post-spraydrying and post-SGF viabilities were obtained. Successful encapsulation of different lactobacilli probiotics via the proposed spray-drying technique highlights potential of this procedure to be scaled up for commercial applications.
