2022-04-06 ニューヨーク大学(NYU)
・研究者らは、ミバエの視覚系における脳細胞の発達を制御する10種類の因子をすべて特定し、これらの神経細胞がどのような順序で発達するかも含めて明らかにしました。
・この研究成果は『Nature』誌に掲載され、さまざまな動物で脳の発達がどのように進化してきたかを理解する新しい研究の道を開くとともに、再生医療への手がかりを提供するものと期待されます。
<関連情報>
- https://www.nyu.edu/about/news-publications/news/2022/april/scientists-pinpoint-what-makes-brain-cells-develop-in-a-specific.html
- https://www.nature.com/articles/s41586-022-04564-w
ハエの視覚系における完全な時間軸転写因子シリーズ A complete temporal transcription factor series in the fly visual system
Nikolaos Konstantinides,Isabel Holguera,Anthony M. Rossi,Aristides Escobar,Liébaut Dudragne,Yen-Chung Chen,Thinh N. Tran,Azalia M. Martínez Jaimes,Mehmet Neset Özel,Félix Simon,Zhiping Shao,Nadejda M. Tsankova,John F. Fullard,Uwe Walldorf,Panos Roussos &Claude Desplan
nature Published: 06 April 2022
Abstract
The brain consists of thousands of neuronal types that are generated by stem cells producing different neuronal types as they age. In Drosophila, this temporal patterning is driven by the successive expression of temporal transcription factors (tTFs). Here we used single-cell mRNA sequencing to identify the complete series of tTFs that specify most Drosophila optic lobe neurons. We verify that tTFs regulate the progression of the series by activating the next tTF(s) and repressing the previous one(s), and also identify more complex mechanisms of regulation. Moreover, we establish the temporal window of origin and birth order of each neuronal type in the medulla and provide evidence that these tTFs are sufficient to explain the generation of all of the neuronal diversity in this brain region. Finally, we describe the first steps of neuronal differentiation and show that these steps are conserved in humans. We find that terminal differentiation genes, such as neurotransmitter-related genes, are present as transcripts, but not as proteins, in immature larval neurons. This comprehensive analysis of a temporal series of tTFs in the optic lobe offers mechanistic insights into how tTF series are regulated, and how they can lead to the generation of a complete set of neurons.
