未熟児や呼吸器疾患を持つ成人の呼吸を楽にする合成肺活量コーティング剤 Synthetic lung coatings can help premature infants and adults with respiratory problems breathe easier
2022-04-06 ミネソタ大学
・「肺サーファクタントの主な目的は、呼吸に必要なエネルギー量を最小限に抑えることです」と、論文の主執筆者Cain Valtierrez-Gaytanは語っています。
・この論文は、米国科学振興協会が発行する査読付き学際的科学雑誌『Science Advances』に掲載されています。
<関連情報>
- https://cse.umn.edu/college/news/study-discovers-molecular-properties-lung-surfactants-could-lead-better-treatments
- https://www.science.org/doi/10.1126/sciadv.abl9152
リン脂質-コレステロール単分子膜における平衡形態の自発的進化 Spontaneous evolution of equilibrium morphology in phospholipid-cholesterol monolayers
CAIN VALTIERREZ-GAYTAN,XJOSEPH M. BARAKAT,MITCHELL KOHLER,KHANH KIEU,BENJAMIN L. STOTTRUP AND JOSEPH A. ZASADZINSKI
ScienceAdvances Published:6 Apr 2022
DOI: 10.1126/sciadv.abl9152
Abstract
Competition between intradomain electrostatic repulsions and interdomain line tension leads to domain shape transitions in phase-separating lipid monolayers. The question remains if these morphologies are energy minima or are kinetically trapped metastable states. We show the reversible evolution of uniform width stripe domains from polydisperse semicircular domains in monolayers of dipalmitoylphosphatidylcholine (DPPC), hexadecanol (HD) or palmitic acid (PA), and dihydrocholesterol (DChol). The initial semicircular domains grow at a fixed 2:1 DPPC:HD (or PA) stoichiometry, depleting the liquid phase of HD, leaving behind a liquid enriched in DPPC and DChol. At higher surface pressures, the remaining DPPC precipitates onto existing domains, decreasing the ratio of line tension to the square of the dipole density difference, λ/μ2. Theory predicts that, as λ/μ2 decreases, circular domains reversibly transform to uniform width stripes as the minimum energy structure. Measuring the stripe width provides the first estimates of λ/μ2 at liquid condensed–liquid expanded phase coexistence.
