音で部分的に破壊された腫瘍は再発しない(Tumors partially destroyed with sound don’t come back)

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ミシガン大学がラットで開発した技術は、がんや神経疾患の治療成績を改善する可能性がある Technique pioneered in rats at the University of Michigan could improve outcomes for cancer and neurological conditions

2022-04-18 ミシガン大学

・ミシガン大学が開発した非侵襲的音響技術は、ラットの肝臓腫瘍を破壊し、がん細胞を死滅させ、免疫系を刺激してさらなる転移を防ぐもので、人間のがん治療の改善につながる可能性があります。
・肝臓腫瘍の体積の50%から75%だけを破壊することで、ラットの免疫システムは残りの腫瘍を除去することができ、80%以上の動物で再発や転移の証拠が見られませんでした。
・腫瘍全体を標的としなくても、腫瘍を退縮させ、将来の転移のリスクを減らすことができます」と、U-M大学の生体医工学教授で『Cancers』誌の研究代表者であるZhen Xuは述べている。

<関連情報>

ラット肝腫瘍モデルにおける肝内転移の発生に及ぼすヒストトリプシーの影響 Impact of Histotripsy on Development of Intrahepatic Metastases in a Rodent Liver Tumor Model

Tejaswi Worlikar,Man Zhang,Anutosh Ganguly,Timothy L. Hall,Jiaqi Shi,Lili Zhao,Fred T. Lee,Mishal Mendiratta-Lala,Clifford S. Cho and Zhen Xu
MDPI  Published: 22 March 2022
https://doi.org/10.3390/cancers14071612

Abstract

Histotripsy has been used for tumor ablation, through controlled, non-invasive acoustic cavitation. This is the first study to evaluate the impact of partial histotripsy ablation on immune infiltration, survival outcomes, and metastasis development, in an in vivo orthotopic, immunocompetent rat HCC model (McA-RH7777). At 7–9 days post-tumor inoculation, the tumor grew to 5–10 mm, and ~50–75% tumor volume was treated by ultrasound-guided histotripsy, by delivering 1–2 cycle histotripsy pulses at 100 Hz PRF (focal peak negative pressure P– >30 MPa), using a custom 1 MHz transducer. Complete local tumor regression was observed on MRI in 9/11 histotripsy-treated rats, with no local recurrence or metastasis up to the 12-week study end point, and only a <1 mm residual scar tissue observed on histology. In comparison, 100% of untreated control animals demonstrated local tumor progression, developed intrahepatic metastases, and were euthanized at 1–3 weeks. Survival outcomes in histotripsy-treated animals were significantly improved compared to controls (p-value < 0.0001). There was evidence of potentially epithelial-to-mesenchymal transition (EMT) in control tumor and tissue healing in histotripsy-treated tumors. At 2- and 7-days post-histotripsy, increased immune infiltration of CD11b+, CD8+ and NK cells was observed, as compared to controls, which may have contributed to the eventual regression of the untargeted tumor region in histotripsy-treated tumors.

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