蚊を傷つけ、益虫を逃がす機会 Opportunity to hurt mosquitoes but spare beneficial insects
2022-06-14 カリフォルニア大学リバーサイド校(UCR)
蚊は、ミバエが持っている4つのトランスポータータンパク質のうち、3つしか持っていないのだ。蚊は最も重要な、主要なエクジソントランスポーターを欠いている。
この発見は、有益なハチや他の受粉媒介者に害を与えない蚊専用の殺虫剤への扉を開くものである。しかし、この研究で使われたイエネコのように、ジカ熱、デング熱、黄熱病、チクングニヤ熱などのウイルスを媒介する蚊には影響がある。
<関連情報>
- https://news.ucr.edu/articles/2022/06/14/genetic-discovery-could-spell-mosquitoes-death-knell
- https://www.pnas.org/doi/full/10.1073/pnas.2202932119
蚊のエクジソンインポーターの発生・生殖における必須機能 Essential functions of mosquito ecdysone importers in development and reproduction
Lewis V. Hun, Naoki Okamoto, Eisuke Imura,, Roilea Maxson, Riyan Bittar, and Naoki Yamanaka
Proceedings of the National Academy of Sciences Published:June 13, 2022
DOI:https://doi.org/10.1073/pnas.2202932119
Abstract
The primary insect steroid hormone ecdysone requires a membrane transporter to enter its target cells. Although an organic anion-transporting polypeptide (OATP) named Ecdysone Importer (EcI) serves this role in the fruit fly Drosophila melanogaster and most likely in other arthropod species, this highly conserved transporter is apparently missing in mosquitoes. Here we report three additional OATPs that facilitate cellular incorporation of ecdysone in Drosophila and the yellow fever mosquito Aedes aegypti. These additional ecdysone importers (EcI-2, -3, and -4) are dispensable for development and reproduction in Drosophila, consistent with the predominant role of EcI. In contrast, in Aedes, EcI-2 is indispensable for ecdysone-mediated development, whereas EcI-4 is critical for vitellogenesis induced by ecdysone in adult females. Altogether, our results indicate unique and essential functions of these additional ecdysone importers in mosquito development and reproduction, making them attractive molecular targets for species- and stage-specific control of ecdysone signaling in mosquitoes.
