2024-10-10 マサチューセッツ大学アマースト校
<関連情報>
- https://www.umass.edu/news/article/new-device-id-biomarkers-breastfeeding-complications-developed-umass-amherst-led-team
- https://www.sciencedirect.com/science/article/pii/S0925400524013820
母乳中のナトリウムイオンを高精度微量全分析 High-precision micro-total analysis of sodium ions in breast milk
Huilu Bao, Xiao Fan, Xiaoyu Zhang, Xin Zhang, Katie T. Kivlighan, Sallie S. Schneider, Jianghong Liu, Alan T. Charlie Johnson, Kathleen F. Arcaro, Jinglei Ping
Sensors and Actuators B: Chemical Available online: 17 September 2024
DOI:https://doi.org/10.1016/j.snb.2024.136652
Highlights
- Lab-on-chip device for detecting sodium ions in breast milk at lab-level accuracy.
- Integration of micro electrodialysis with graphene-based biosensing.
- High-efficiency isolation and high-sensitivity quantification of sodium ions.
Abstract
Measuring sodium ion concentration in breast milk can provide crucial health information for both mother and infant, including early signs of low-grade infection and reduced milk supply. Traditional sensing methods are slow, bulky, expensive, and require skilled operators. Here, we develop a coverslip-sized, high-precision lab-on-a-chip device that processes and detects sodium ions in human breast milk. The device uses micro-electrodialysis to extract sodium ions into a simple acceptor solution with 92 ± 3 % efficiency and employs a graphene ion-selective sensor for high-performance quantification. We demonstrate a straightforward calibration strategy, enabling the device to measure breast-milk sodium ion levels in 141 seconds, with accuracy comparable to inductively coupled plasma mass spectrometry. Our approach offers a promising pathway to efficient, point-of-care diagnosis of conditions associated with metal-ion levels in complex liquid-biopsy samples.
