2025-07-30 アメリカ国立衛生研究所(NIH)
<関連情報>
- https://www.nih.gov/news-events/news-releases/beta-hpv-can-directly-cause-skin-cancer-immunocompromised-people
- https://www.nejm.org/doi/full/10.1056/NEJMoa2502114
T細胞受容体シグナル伝達の回復による扁平上皮癌の解決 Resolution of Squamous-Cell Carcinoma by Restoring T-Cell Receptor Signaling
Peiying Ye, Ph.D., Jenna R.E. Bergerson, M.D., M.P.H., Isaac Brownell, M.D., Ph.D., Gabriel J. Starrett, Ph.D., Roshini S. Abraham, Ph.D., Megan V. Anderson, R.N., B.A., Triscia Martin, P.A., M.S., +10 , and Andrea Lisco, M.D., Ph.D.
The New England Journal of Medicine Published: July 30, 2025
DOI:10.1056/NEJMoa2502114
Summary
Cutaneous squamous-cell carcinoma (SCC) is primarily caused by oncogenesis mediated by ultraviolet radiation, and β-human papillomavirus (β-HPV) is believed to be a mere facilitator that is dispensable for the maintenance of cutaneous SCC. Here, we describe a woman with benign and malignant HPV-related diseases that include a recurrent, unresectable, invasive cutaneous SCC with β-HPV19 genomic integration in the context of germline pathogenic mutations in ZAP70, an adapter required for T-cell receptor (TCR) signal transduction. Restoration of the integrity of TCR signaling by allogeneic hematopoietic-cell transplantation led to the resolution of all HPV-related diseases, thereby revealing a direct role of β-HPV in skin carcinogenesis in hosts with defective adaptive T-cell responses. (Funded by the National Institutes of Health.)
